DCE Recommended Literature¶

Key manuscripts in perfusion MRI, curated by OSIPI Task Force 5.2 for those getting started.

Text Books¶

• Editors: Hai-Ling Margaret Cheng, ‪Gustav J. Strijkers. Quantitative Perfusion MRI: Techniques, Applications and Practical Considerations. First edition. August 22, 2023. ISBN: 9780323952095
• Editor: Paul Tofts. Quantitative MRI of the Brain: Measuring Changes Caused by Disease, chapter 11. First published August 2003.
• Lippincott Williams and Wilkins. MR and CT Perfusion and Pharmacokinetic Imaging: Clinical Applications and Theoretical Principles. First Edition. May 11, 2016. ISBN-10 ‏ : ‎ 1451147155
• Nicole Seiberlich, Vikas Gulani, Adrienne Campbell-Washburn, Steven Sourbron, Mariya Ivanova Doneva, Fernando Calamante, Houchun Harry Hu. Quantitative Magnetic Resonance Imaging. Of Series: Advances in Magnetic Resonance Technology and Applications. Section 2: Perfusion and Permeability, Chapters 11&13, Volume 1. First Edition, December 10, 2020. ISBN-10 ‏ : ‎ 0128170573
• Donald W. McRobbie, Elizabeth A. Moore, Martin J. Graves, Martin R. Prince. MRI from Picture to Proton. 2^nd Edition. October 2009. Cambridge University Press
• Malcolm H. Levitt. Spin Dynamics: Basics of Nuclear Magnetic Resonance, 2^nd Edition. March 2008. ISBN: 978-0-470-51117-6

General Overview¶

• Sourbron SP, Buckley DL. On the scope and interpretation of the Tofts models for DCE-MRI. Magn Reson Med. 2011 Sep;66(3):735-45.
• Cuenod CA, Balvay D. Perfusion and vascular permeability: basic concepts and measurement in DCE-CT and DCE-MRI. Diagn Interv Imaging. 2013 Dec;94(12):1187-204.
• Khalifa F, Soliman A, El-Baz A, Abou El-Ghar M, El-Diasty T, Gimel'farb G, Ouseph R, Dwyer AC. Models and methods for analyzing DCE-MRI: a review. Med Phys. 2014 Dec;41(12):124301.
• Quarles CC, Bell LC, Stokes AM. Imaging vascular and hemodynamic features of the brain using dynamic susceptibility contrast and dynamic contrast enhanced MRI. Neuroimage. 2019 Feb 15;187:32-55.
• Dyke JP, Aaron RK. Noninvasive methods of measuring bone blood perfusion. Ann N Y Acad Sci. 2010 Mar;1192(1):95-102.
• Lohrke, J., Frenzel, T., Endrikat, J., Alves, F. C., Grist, T. M., Law, M., Lee, J. M., Leiner, T., Li, K.-C., Nikolaou, K., Prince, M. R., Schild, H. H., Weinreb, J. C., Yoshikawa, K., & Pietsch, H. 25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives. Advances in Therapy, 33(1), 1–28.
• Koh, T. S., Bisdas, S., Koh, D. M., & Thng, C. H. Fundamentals of tracer kinetics for dynamic contrast-enhanced MRI. Journal of Magnetic Resonance Imaging, 2011. 34(6), 1262–1276.
• Petralia, G., Summers, P. E., Agostini, A., Ambrosini, R., Cianci, R., Cristel, G., Calistri, L., & Colagrande, S. Dynamic contrast-enhanced MRI in oncology: how we do it. Radiol Med. 2020 Dec;125(12):1288-1300.
• Hanson, L. G. Introduction to Magnetic Resonance Imaging Techniques. 2009
• Hanson, L. G. The Ups and Downs of Classical and Quantum Formulations of Magnetic Resonance. In Anthropic Awareness: The Human Aspects of Scientific Thinking in NMR Spectroscopy and Mass Spectrometry (pp. 141–171). Elsevier Inc. 2015

Seminal Papers¶

• Tofts PS. Modeling tracer kinetics in dynamic Gd-DTPA MR imaging. J Magn Reson Imaging. 1997 Jan-Feb;7(1):91-101.
• Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, Port RE, Taylor J, Weisskoff RM. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999 Sep;10(3):223-32.
• Brix G, Semmler W, Port R, Schad LR, Layer G, Lorenz WJ. Pharmacokinetic parameters in CNS Gd-DTPA enhanced MR imaging. J Comput Assist Tomogr. 1991 Jul-Aug;15(4):621-8.
• Parker GJ, Roberts C, Macdonald A, Buonaccorsi GA, Cheung S, Buckley DL, Jackson A, Watson Y, Davies K, Jayson GC. Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. Magn Reson Med. 2006 Nov;56(5):993-1000.
• Rohrer M, Bauer H, Mintorovitch J, Requardt M, Weinmann HJ. Comparison of magnetic properties of MRI contrast media solutions at different magnetic field strengths. Invest Radiol. 2005 Nov;40(11):715-24.

Clinical Applications¶

• Dijkhoff RAP, Beets-Tan RGH, Lambregts DMJ, Beets GL, Maas M. Value of DCE-MRI for staging and response evaluation in rectal cancer: A systematic review. Eur J Radiol. 2017 Oct;95:155-168.
• Thrippleton MJ, Backes WH, Sourbron S, Ingrisch M, van Osch MJP, Dichgans M, Fazekas F, Ropele S, Frayne R, van Oostenbrugge RJ, Smith EE, Wardlaw JM. Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations. Alzheimers Dement. 2019 Jun;15(6):840-858.
• Dickie BR, Parker GJM, Parkes LM. Measuring water exchange across the blood-brain barrier using MRI. Prog Nucl Magn Reson Spectrosc. 2020 Feb;116:19-39.
• O’Connor, J. P. B., Aboagye, E. O., Adams, J. E., Aerts, H. J. W. L., Barrington, S. F., Beer, A. J., Boellaard, R., Bohndiek, S. E., Brady, M., Brown, G., Buckley, D. L., Chenevert, T. L., Clarke, L. P., Collette, S., Cook, G. J., deSouza, N. M., Dickson, J. C., Dive, C., Evelhoch, J. L., … Waterton, J. C. Imaging biomarker roadmap for cancer studies. Nat Rev Clin Oncol. 2017 Mar;14(3):169-186
• Alonzi, R., Padhani, A.R. and Allen, C. Dynamic contrast enhanced MRI in prostate cancer. Eur J Radiol. 2007 Sep;63(3):335-50.
• Thng, C. H., Koh, T. S., Collins, D. J., & Koh, D. M. Perfusion magnetic resonance imaging of the liver. World Journal of Gastroenterology
• Teo, Q. Q., Thng, C. H., Koh, T. S., & Ng, Q. S. Dynamic Contrast-enhanced Magnetic Resonance Imaging: Applications in Oncology. Clin Oncol (R Coll Radiol). 2014 Oct;26(10):e9-20.

Acquisition¶

• QIBA MR Biomarker Committee, Quantitative Imaging Biomarkers Alliance. MR DCE-MRI Quantification (DCEMRI-Q), 2020.

Analysis¶

• Sourbron SP, Buckley DL. Classic models for dynamic contrast-enhanced MRI. NMR Biomed. 2013 Aug;26(8):1004-27.
• Sourbron SP, Buckley DL. Tracer kinetic modelling in MRI: estimating perfusion and capillary permeability. Phys Med Biol. 2012 Jan 21;57(2):R1-33.
• Ingrisch, M., Sourbron, S. Tracer-kinetic modeling of dynamic contrast-enhanced MRI and CT: a primer. J Pharmacokinet Pharmacodyn 2013 Jun;40(3):281-300.
• Kim H. Variability in Quantitative DCE-MRI: Sources and Solutions. J Nat Sci. 2018;4(1):e484. PMID: https://pubmed.ncbi.nlm.nih.gov/29527572
• Calamante F. Arterial input function in perfusion MRI: a comprehensive review. Prog Nucl Magn Reson Spectrosc. 2013 Oct;74:1-32.
• Hanson, E. A., Sandmann, C., Malyshev, A., Lundervold, A., Modersitzki, J., & Hodneland, E. Estimating the discretization dependent accuracy of perfusion in coupled capillary flow measurements. PLoS One. 2018 Jul 20;13(7):e0200521.