base

base

Base class for DSC leakage correction methods (OSIPI: P.LC1.001).

Leakage correction addresses contrast agent extravasation across the blood-brain barrier, which contaminates the delta-R2* signal used to compute perfusion parameters.

References

.. [1] OSIPI CAPLEX, https://osipi.github.io/OSIPI_CAPLEX/ .. [2] Dickie BR et al. MRM 2024. doi:10.1002/mrm.30101

BaseLeakageCorrector

Bases: BaseComponent

Abstract base class for leakage correction methods (OSIPI: P.LC1.001).

Subclasses implement specific correction algorithms to separate intravascular delta-R2* signal from extravascular leakage contributions, estimating leakage coefficients K1 (OSIPI: Q.LC1.001) and K2 (OSIPI: Q.LC1.002).

References

.. [1] OSIPI CAPLEX, https://osipi.github.io/OSIPI_CAPLEX/

correct abstractmethod

correct(delta_r2, aif, time, mask=None, **kwargs)

Perform leakage correction (OSIPI: P.LC1.001).

PARAMETER	DESCRIPTION
delta_r2	Uncorrected delta-R2* data. TYPE: NDArray[floating]
aif	Arterial input function. TYPE: NDArray[floating]
time	Time points in seconds. TYPE: NDArray[floating]
mask	Brain mask. TYPE: NDArray[bool_] | None DEFAULT: None
**kwargs	Method-specific parameters. TYPE: Any DEFAULT: {}

RETURNS	DESCRIPTION
LeakageCorrectionResult	Corrected data and leakage coefficients.